Francis Kayali's music has been performed by the Charleston Symphony Orchestra, the North/South Consonance Chamber Orchestra, the Boston Modern Orchestra Project (BMOP), the What's Next? Ensemble, the West Point Woodwind Quintet, the Parhelion Trio, and the Bateira Trio.
His Trio for Clarinet, Violin and Piano was performed at the 2008 ACA Festival of American Music at Symphony Space in New York City. In 2014, Masks, for flute, viola, and contrabass, was performed by the Bateira Trio at Carnegie Hall.
Kayali studied composition with Elliott Schwartz and Robert Greenlee at Bowdoin College, then with Perry Goldstein and Peter Winkler at SUNY Stony Brook. In 2009, Kayali earned the Doctor of Musical Arts degree in composition from the University of Southern California's Thornton School of Music, where he studied with Frank Ticheli, Tamar Diesendruck, and Donald Crockett.
In Fall 2013, after teaching for three years in the San Francisco Bay area, Francis joined the Fine Arts Department at Saint Anselm College as Assistant Professor of Music.